Department of Nuclear Medicine, Medical Centre, Zajecar, Yugoslawia
نویسندگان
چکیده
Radio receptor assays for detection of TSH receptor antibodies in serum are typically based on binding competition of TSH-R antibodies and 125 I “labeled” TSH for membrane preparation of thyrocytes (TBII tests). Sensitivity of available tests utilizing porcine cell membranes was around 80%. New test (TRAK Dyno human, BRAHMS) utilizes human recombinant TSH receptor and human standard material that are supposed to improve performance of the test. We have compared results of these two assays. Sensitivity of TRAK Assay tested in 356 patients with untreated Graves’ disease was 85% and 97,5% for TRAK Dyno human in 111 newly diagnosed patients. Both tests were performed from the same serum specimen for 60 of all investigated patients . TRAK Assay was positive in 50 patients (83,2%) and TRAK Dyno human in 59 patients (98,3%). Specificity of the new radio receptor assay was also improved.
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تاریخ انتشار 2008